What is the research dosage of sermorelin?

The dosing references converge on approximately 300 mcg once nightly (also expressed as around 10 mcg/kg), given subcutaneously and timed to before bed so it works with the body's own nocturnal growth-hormone pulse. These figures are reproduced strictly as a laboratory research reference and are not a human dosing protocol or medical advice.

What is sermorelin's half-life?

Sermorelin's half-life is reported at roughly 11–12 minutes after subcutaneous or intravenous administration — very short. Growth hormone peaks within about 30–60 minutes and returns to baseline within a couple of hours, which is why sermorelin is dosed as a nightly single pulse rather than a long-acting weekly compound.

How is sermorelin different from CJC-1295?

Sermorelin is the plain GHRH(1-29) fragment. CJC-1295 is the same GHRH backbone with stabilising modifications, and in its DAC form it is extended to last days instead of minutes. Titan's in-stock blend uses no-DAC (short-acting) CJC-1295 with ipamorelin. Chain length, the modifications, and DAC status are what separate the GHRH analogs.

Does Titan sell sermorelin?

Titan does not stock standalone sermorelin. The in-catalog GHRH-analog is the CJC-1295 + Ipamorelin blend, a genuine peptide combination sold as a research-use-only reagent. This page is an informational dosing reference and an honest pointer to what Titan actually carries.

Why is sermorelin dosed at night?

Because it is short-acting and works by amplifying the body's own growth-hormone release, sermorelin is timed to the natural nocturnal GH pulse — dosed once nightly, well after the last meal. The timing is treated as part of the protocol, not an afterthought, precisely because the compound clears within a couple of hours.

Sermorelin · GHRH(1-29) · research use only

Sermorelin dosage is short-acting on purpose — which is the whole point of the timing.

Sermorelin is GHRH(1-29), the shortest biologically active fragment of natural growth-hormone-releasing hormone. That truncation is what defines its dosing: it has a very short half-life measured in minutes, GH rises and falls within a couple of hours, and the research protocols therefore dose it once nightly to ride the body's own sleep-time GH pulse. This page reproduces the ~300 mcg nightly figure from the dosing references, the ~11–12 minute half-life behind before-bed timing, and how the shortest GHRH analog differs from the modified CJC-1295 that Titan actually stocks — framed as a research reference, not a human protocol. Titan does not sell standalone sermorelin; the in-catalog GHRH-analog is the CJC-1295 + Ipamorelin blend.

In-stock GHRH-analog: CJC-1295 + Ipamorelin — $119.99 Ipamorelin vs Sermorelin

~300 mcg nightly, timed to sleep

The dosing references converge on roughly 300 mcg once nightly, taken well after the last meal, with study protocols also expressing it per bodyweight (on the order of 10 mcg/kg nightly). The 'nightly' part is not arbitrary: sermorelin works with the body's endogenous nocturnal GH pulse, so the timing is as much a part of the protocol as the number. Reproduced here as a research reference, not a human instruction.

How it pairs with a GHRP →

~11–12 minute half-life

Sermorelin's half-life is reported at roughly 11–12 minutes after subcutaneous or IV administration — extremely short. Peak GH follows within about 30–60 minutes and returns to baseline within a couple of hours. That brevity is why it is a nightly, single-pulse compound rather than a once-weekly one, and it is the sharpest contrast with the DAC-extended version of CJC-1295, which was engineered to last days rather than minutes.

Compare the blend's kinetics →

Reconstitution math

Sermorelin ships lyophilized and the working concentration is set by the water added. As a worked example, a 5 mg vial in 2.5 mL of bacteriostatic water yields 2 mg/mL, so 0.15 mL on a U-100 insulin syringe draws 300 mcg. Confirm your own vial's stated mass and run the numbers before any in-vitro modelling rather than assuming a concentration.

Run the numbers →

Shortest GHRH analog vs CJC-1295

Sermorelin is the bare GHRH(1-29) sequence; CJC-1295 is that same GHRH backbone modified for stability, and in DAC form extended dramatically in duration. Titan's in-stock blend uses the no-DAC (short-acting) CJC-1295 paired with ipamorelin, a selective GHRP. If a protocol is choosing between GHRH analogs, chain length, the stabilising modifications, and DAC status are the variables that actually separate them.

See the in-stock blend →

Verify the 29-residue sequence

Because sermorelin is a defined 29-amino-acid peptide, a meaningful certificate confirms that full sequence by mass spectrometry plus an HPLC main-peak purity against a stated target. A truncated or wrong-length peptide can pass a loose 'purity' check while being the wrong molecule — so identity, not just the purity number, is what matters for a GHRH fragment.

How to read a COA →

Research-use framing

These figures describe doses used in sermorelin research, reproduced strictly as a laboratory reference for in-vitro and modelling work — not instructions for human use. Sermorelin is a prescription compound; Titan does not sell it and supplies only research-use-only reagents, not for human or animal consumption. Nothing here is medical or dosing advice.

Research-use policy →

The detail, in plain terms

The sermorelin reference, in one table.

Sermorelin's dosing is driven entirely by how short-acting it is. These are the variables a researcher weighs when modelling it — reproduced as a reference, not a human protocol. Titan stocks the CJC-1295 + Ipamorelin blend, not standalone sermorelin.

Compound: Sermorelin — GHRH(1-29), the shortest active fragment of GHRH.
Research dose: ≈300 mcg once nightly (also expressed as ~10 mcg/kg), subcutaneous.
Timing: Before bed, well after the last meal — rides the nocturnal GH pulse.
Half-life: ≈11–12 minutes; peak GH ~30–60 min, back to baseline within ~2 h.
Reconstitution: 5 mg vial + 2.5 mL BAC water → 2 mg/mL (0.15 mL ≈ 300 mcg).
Titan catalog: Not stocked standalone. In-catalog GHRH-analog: CJC-1295 + Ipamorelin blend, $119.99.

Questions researchers ask

Before you order.

What is the research dosage of sermorelin?: The dosing references converge on approximately 300 mcg once nightly (also expressed as around 10 mcg/kg), given subcutaneously and timed to before bed so it works with the body's own nocturnal growth-hormone pulse. These figures are reproduced strictly as a laboratory research reference and are not a human dosing protocol or medical advice.
What is sermorelin's half-life?: Sermorelin's half-life is reported at roughly 11–12 minutes after subcutaneous or intravenous administration — very short. Growth hormone peaks within about 30–60 minutes and returns to baseline within a couple of hours, which is why sermorelin is dosed as a nightly single pulse rather than a long-acting weekly compound.
How is sermorelin different from CJC-1295?: Sermorelin is the plain GHRH(1-29) fragment. CJC-1295 is the same GHRH backbone with stabilising modifications, and in its DAC form it is extended to last days instead of minutes. Titan's in-stock blend uses no-DAC (short-acting) CJC-1295 with ipamorelin. Chain length, the modifications, and DAC status are what separate the GHRH analogs.
Does Titan sell sermorelin?: Titan does not stock standalone sermorelin. The in-catalog GHRH-analog is the CJC-1295 + Ipamorelin blend, a genuine peptide combination sold as a research-use-only reagent. This page is an informational dosing reference and an honest pointer to what Titan actually carries.
Why is sermorelin dosed at night?: Because it is short-acting and works by amplifying the body's own growth-hormone release, sermorelin is timed to the natural nocturnal GH pulse — dosed once nightly, well after the last meal. The timing is treated as part of the protocol, not an afterthought, precisely because the compound clears within a couple of hours.