Tesamorelin · GHRH(1-44) analog · research use only
Tesamorelin is dosed once daily because it clears in minutes, not days.
Tesamorelin is a synthetic analog of full-length growth-hormone-releasing hormone, GHRH(1-44), stabilised at the N-terminus. Its dosing is defined by one fact: the elimination half-life reported on the approved label is only about 8 minutes. That is why the label figure is a fixed 2 mg once daily by subcutaneous injection rather than a weekly shot — the molecule triggers a GH pulse and is gone, so the schedule is daily by design. This page reproduces the 2 mg daily reference and the ~8-minute half-life from the prescribing information, and explains why a 44-residue GHRH analog is a different animal from the shorter, DAC-tunable CJC-1295 that Titan carries. Framed as a research reference, not a human protocol. Titan does not sell tesamorelin; the in-catalog GHRH-analog is the CJC-1295 + Ipamorelin blend.
2 mg once daily (label figure)
The approved reference dose is a fixed 2 mg once daily, given subcutaneously — not titrated per bodyweight the way an incretin ladder is. The trial that supports it randomised subjects to tesamorelin 2 mg subcutaneously daily over months. It is reproduced here strictly as a laboratory research reference for in-vitro and modelling work, not as a human dosing instruction.
How it compares to CJC-1295 →~8-minute half-life
The prescribing information reports a mean elimination half-life of roughly 8 minutes in healthy subjects after a single subcutaneous dose. That is the shortest clock in this whole GHRH conversation — shorter than sermorelin's ~11–12 minutes — and it is the reason the schedule is daily rather than weekly. A researcher modelling tesamorelin is modelling a sharp, brief pulse, not an accumulating depot.
Compare the blend's kinetics →Reconstitution math
Tesamorelin ships lyophilized and the working concentration is set by the diluent volume. As a worked example, a 2 mg vial reconstituted in 2 mL of bacteriostatic water yields 1 mg/mL, so a 2 mL draw represents the whole 2 mg reference figure. Always confirm your own vial's stated mass and run the arithmetic before any in-vitro modelling rather than assuming a concentration.
Run the numbers →GHRH(1-44) vs the shorter analogs
Tesamorelin is the full 44-residue GHRH sequence with an N-terminal trans-3-hexenoyl modification; sermorelin is the truncated GHRH(1-29); CJC-1295 is a GHRH(1-29)-based analog that in DAC form is engineered to last days. Chain length and the stabilising modification are exactly what separate them — and why their dosing schedules run from daily (tesamorelin, sermorelin) to weekly (DAC CJC-1295).
Full-length vs 1-29 backbone →Verify chain length, not just purity
Because tesamorelin is a defined 44-amino-acid peptide with a specific N-terminal modification, a meaningful certificate confirms that full sequence and the modification by mass spectrometry, alongside an HPLC main-peak purity against a stated target. A truncated 43- or 29-residue peptide can still post a clean 'purity' number while being the wrong molecule — identity is what matters for a full-length GHRH analog.
How to read a COA →Research-use framing
These figures describe doses used in tesamorelin research and reproduced from the prescribing information strictly as a laboratory reference for in-vitro and modelling work — not instructions for human use. Tesamorelin is a prescription compound; Titan does not sell it and supplies only research-use-only reagents, not for human or animal consumption. Nothing here is medical or dosing advice.
Research-use policy →The detail, in plain terms
The tesamorelin reference, in one table.
Tesamorelin's schedule is driven entirely by how short-acting it is. These are the variables a researcher weighs when modelling it — reproduced as a reference, not a human protocol. Titan stocks the CJC-1295 + Ipamorelin blend, not tesamorelin.
- Compound
- Tesamorelin — a stabilised analog of full-length GHRH(1-44).
- Research dose
- 2 mg once daily, subcutaneous (fixed label figure, not per-kg).
- Timing
- Once daily — the ~8-minute clearance rules out a weekly schedule.
- Half-life
- ≈8 minutes (label); the shortest clock among the common GHRH analogs.
- Reconstitution
- 2 mg vial + 2 mL BAC water → 1 mg/mL (2 mL ≈ the 2 mg figure).
- Titan catalog
- Not stocked. In-catalog GHRH-analog: CJC-1295 + Ipamorelin blend, $119.99.
Questions researchers ask
Before you order.
- What is the research dosage of tesamorelin?
- The approved reference is a fixed 2 mg once daily by subcutaneous injection, and the supporting trial dosed subjects at tesamorelin 2 mg subcutaneously daily. It is not titrated per bodyweight. These figures are reproduced strictly as a laboratory research reference and are not a human dosing protocol or medical advice.
- What is tesamorelin's half-life?
- The prescribing information reports a mean elimination half-life of about 8 minutes in healthy subjects after a single subcutaneous dose — the shortest clock among the common GHRH analogs. That very rapid clearance is why the dose is scheduled once daily rather than weekly.
- How is tesamorelin different from CJC-1295 and sermorelin?
- Tesamorelin is the full 44-residue GHRH sequence with an N-terminal modification; sermorelin is the truncated GHRH(1-29); CJC-1295 is a GHRH(1-29)-based analog that in DAC form is engineered to last days. Chain length and the stabilising modification separate them, and that is why their schedules range from daily to weekly. Titan stocks the no-DAC CJC-1295 + Ipamorelin blend.
- Does Titan sell tesamorelin?
- No. Titan does not stock tesamorelin. The in-catalog GHRH-analog is the CJC-1295 + Ipamorelin blend, a genuine peptide combination sold as a research-use-only reagent. This page is an informational dosing reference and an honest pointer to what Titan actually carries.
- Why is tesamorelin dosed daily instead of weekly?
- Because its half-life is only about 8 minutes. The molecule triggers a growth-hormone pulse and clears almost immediately, so there is no depot to sustain a weekly interval — the schedule has to be daily. That is the sharpest contrast with a DAC-modified CJC-1295, which was purpose-built to persist for days.