Does Titan sell SS-31 (Elamipretide)?

No — SS-31 is not a Titan catalog product. Titan's RUO line centers on in-house-tested research peptides such as BPC-157, TB-500, retatrutide, the CJC-1295 + Ipamorelin blend, and pre-mixed nasal-format peptides. Rather than list a peptide with unnatural residues it does not verify in-house, Titan points researchers to what it does stock and to the COA standard that applies to any research compound.

Why do 'unnatural residues' matter when buying SS-31?

SS-31 is built from two building blocks that are not standard amino acids: a D-configured arginine and a 2',6'-dimethyltyrosine. Each can be wrong in a way a bare purity number won't show. The dimethyltyrosine carries two extra methyl groups worth roughly 28 daltons, so a batch made with plain tyrosine is about 28 Da lighter — a gap a low-resolution mass spectrum can miss. The D-arginine is a chirality question that ordinary reversed-phase purity is largely blind to. A credible COA shows accurate-mass MS and the HPLC chromatogram so these are actually distinguished. This is a verification point, not a claim about any effect.

What should a real SS-31 COA show?

A credible lot-matched certificate should confirm identity as the correct aromatic-cationic tetrapeptide (HPLC chromatogram shown plus accurate-mass MS, ideally with an orthogonal check on the D-arginine residue), resolve purity from that chromatogram rather than a bare figure, note the C-terminal amide and water content, and carry a lot number that matches the code on the unit you receive. A generic 'third-party tested, 99% pure' badge with none of that is not verification for a peptide with non-standard residues.

Is SS-31 for human use?

No. Anything discussed here is strictly for in-vitro laboratory research. SS-31 supplied as a research chemical is not for human or animal consumption, and no cardiac, mitochondrial, energy, anti-aging, or any other outcome is claimed for it. Nothing on this page is a dosing schedule or a human-use protocol — it is a sourcing and verification guide only.

Where to buy SS-31 (Elamipretide) · research sourcing & COA

Where to buy SS-31 for research — and why its release sheet has to prove two unnatural residues.

SS-31 — also written Elamipretide or MTP-131 — is one of the most-searched compounds in mitochondrial research, and that demand has drawn a field of sellers whose only evidence is a '≥99% pure' line and a generic 'third-party tested' badge, often at $199 a vial. The problem is that SS-31 is not an ordinary peptide where a single purity figure carries the meaning. It is a short aromatic-cationic tetrapeptide — D-Arg-2',6'-dimethyltyrosine-Lys-Phe-NH2 — built with two building blocks that are not standard amino acids: a D-configured arginine and a doubly-methylated tyrosine, finished as a C-terminal amide. Each of those non-standard residues is something a buyer should be able to see confirmed on a certificate, because each one can be wrong in a way a bare purity percentage will never reveal. This page is written for researchers sourcing SS-31 for laboratory use: what a real lot-matched COA should actually prove, why the unnatural-residue question is the one most sellers quietly skip, and where Titan's honest catalog fits. It is for in-vitro laboratory and research use only (RUO). No human-use, dosing, cardiac, energy, anti-aging, or any other outcome is claimed anywhere on this page.

See what Titan actually stocks How to verify a COA

SS-31 is built from two non-standard residues

SS-31 is a four-residue peptide, and two of those four positions are not ordinary amino acids. The first residue is a D-arginine — the mirror-image form, not the natural L. The second is 2',6'-dimethyltyrosine (Dmt), a tyrosine carrying two extra methyl groups on the aromatic ring. Neither is a residue an off-the-shelf synthesis run stocks by default, and both are the parts that define the molecule's aromatic-cationic character. So the first question identity work on SS-31 has to answer is not 'how pure' but 'are the unusual residues actually the ones specified.' A release sheet that treats it like a plain four-mer of standard amino acids has skipped the point.

How to read a COA →

The dimethyltyrosine hides in the mass number

Two methyl groups add roughly 28 daltons of mass. A batch synthesised with plain tyrosine instead of 2',6'-dimethyltyrosine is therefore about 28 daltons lighter than real SS-31 — and on a low-resolution mass spectrometer, or a certificate that only reports one rounded mass, a 28-dalton gap is easy to blur or omit. That is exactly why a credible SS-31 COA shows the actual accurate-mass MS alongside the HPLC chromatogram, rather than a lone purity figure. If the sheet can't distinguish the dimethyl form from an un-methylated impostor, its number is describing 'a tetrapeptide,' not confirmed SS-31.

Current-lot COA checklist →

The D-arginine most purity checks can't see

SS-31 is built with a D-configured arginine, not the natural L form. Standard reversed-phase HPLC purity — the workhorse behind most 'tested' badges — is largely blind to chirality, so a batch that slipped to the L-epimer at that position can still read as high-purity on an ordinary run. Confirming the correct D-residue takes an orthogonal method that bargain sellers rarely mention. It is a quieter failure mode than a missing methyl group, but it is a real one, and it is the kind of thing a buyer only learns to ask about after being burned once.

What COA-verified means →

SS-31 is not MOTS-c — a common mix-up

Both SS-31 and MOTS-c get filed under 'mitochondrial peptides,' and buyers routinely conflate them, but they are different molecules with different verification needs. SS-31 is a synthetic four-residue peptide designed to associate with the inner mitochondrial membrane; MOTS-c is a 16-residue peptide encoded within mitochondrial DNA. One is a short sequence with unnatural residues, the other a longer all-standard sequence — so their release sheets do not check the same things. If you arrived here comparing the two, the dedicated page lays out the split before you buy either.

SS-31 vs MOTS-c →

Why generic 'tested' badges fail on SS-31

A one-size-fits-all 'third-party tested, 99% pure' stamp is designed for a simple peptide of standard amino acids where a purity number carries most of the weight. SS-31 breaks that model on two fronts at once — the D-arginine and the dimethyltyrosine — so a vendor that reuses the same badge it prints for every SKU is signalling it has not thought about what this specific molecule requires. The right buyer response is to ask for the chromatogram and the accurate-mass identity data, and to walk if all they can produce is a recycled certificate with a different product name on top.

Supplier checklist →

What Titan actually stocks (honest)

Titan does not stock SS-31. Titan's RUO catalog is a focused set of in-house-tested research peptides — BPC-157, TB-500, retatrutide, the CJC-1295 + Ipamorelin blend, and a line of pre-mixed nasal-format peptides — not every compound the internet files under 'mitochondrial research.' Rather than list a peptide with unnatural residues it does not verify in-house, Titan points researchers to what it does test and to the verification standard that applies to any research material, SS-31 included. The links here cover the honest sourcing context and the in-catalog options.

Best research peptides (in stock) →

The detail, in plain terms

SS-31 sourcing, in plain terms.

SS-31 is a four-residue aromatic-cationic peptide with a D-arginine and a 2',6'-dimethyltyrosine. Those two non-standard residues — not a headline purity number — decide whether you received the real compound. Verify the unusual residues by accurate-mass MS and an orthogonal chirality check first; treat a lone purity percentage as decoration until the chromatogram and method back it up.

What it is: D-Arg-2',6'-dimethyltyrosine-Lys-Phe-NH2 — an aromatic-cationic tetrapeptide (Elamipretide / MTP-131).
Unnatural residue 1: D-arginine — the mirror-image form; achiral RP-HPLC purity can miss a D→L slip.
Unnatural residue 2: 2',6'-dimethyltyrosine — two extra methyls (~28 Da); plain tyrosine yields a lighter impostor.
Identity check: HPLC chromatogram shown + accurate-mass MS; confirm the D-residue via an orthogonal method.
Also confirm: C-terminal amide, lot number matching the unit received, and water content.
Titan stocks: Not a SKU — honest redirect to in-stock, in-house-tested research peptides.

Questions researchers ask

Before you order.

Does Titan sell SS-31 (Elamipretide)?: No — SS-31 is not a Titan catalog product. Titan's RUO line centers on in-house-tested research peptides such as BPC-157, TB-500, retatrutide, the CJC-1295 + Ipamorelin blend, and pre-mixed nasal-format peptides. Rather than list a peptide with unnatural residues it does not verify in-house, Titan points researchers to what it does stock and to the COA standard that applies to any research compound.
Why do 'unnatural residues' matter when buying SS-31?: SS-31 is built from two building blocks that are not standard amino acids: a D-configured arginine and a 2',6'-dimethyltyrosine. Each can be wrong in a way a bare purity number won't show. The dimethyltyrosine carries two extra methyl groups worth roughly 28 daltons, so a batch made with plain tyrosine is about 28 Da lighter — a gap a low-resolution mass spectrum can miss. The D-arginine is a chirality question that ordinary reversed-phase purity is largely blind to. A credible COA shows accurate-mass MS and the HPLC chromatogram so these are actually distinguished. This is a verification point, not a claim about any effect.
What should a real SS-31 COA show?: A credible lot-matched certificate should confirm identity as the correct aromatic-cationic tetrapeptide (HPLC chromatogram shown plus accurate-mass MS, ideally with an orthogonal check on the D-arginine residue), resolve purity from that chromatogram rather than a bare figure, note the C-terminal amide and water content, and carry a lot number that matches the code on the unit you receive. A generic 'third-party tested, 99% pure' badge with none of that is not verification for a peptide with non-standard residues.
Is SS-31 the same as MOTS-c?: No. Both get grouped under 'mitochondrial peptides,' but they are different molecules. SS-31 is a synthetic four-residue aromatic-cationic peptide with unnatural residues, studied for its association with the inner mitochondrial membrane. MOTS-c is a 16-residue peptide encoded within mitochondrial DNA. Their release sheets verify different things — SS-31 needs unnatural-residue and chirality checks; MOTS-c needs a full 16-mer sequence confirmation. The SS-31 vs MOTS-c page covers the split.
Is SS-31 for human use?: No. Anything discussed here is strictly for in-vitro laboratory research. SS-31 supplied as a research chemical is not for human or animal consumption, and no cardiac, mitochondrial, energy, anti-aging, or any other outcome is claimed for it. Nothing on this page is a dosing schedule or a human-use protocol — it is a sourcing and verification guide only.